By Alfred N. Fonteh,Robert L. Wykle

ISBN-10: 3764369485

ISBN-13: 9783764369484

Arachidonic acid (AA) and different 20 or 22-carbon polyunsaturated fatty acids (PUFAs) are precursors of lipid mediators of irritation referred to as eicosanoids. those mediators are serious in illness techniques and in regulating general telephone functionality. home improvement is necessary in preserving homeostasis and in regulating mobilephone functionality by means of dictating how PUFAs are switched over to lipid mediators of irritation. therefore, PUFA home improvement is a severe strategy within the biosynthesis of a large number of mediators, and figuring out this technique will get to the bottom of larger healing goals for controlling inflammatory ailments akin to bronchial asthma and Alzheimer’s disease.
AA metabolism is defined in an built-in context linking the reworking tactics with the biosynthesis of mediators and illnesses. by way of following the circulate of the substrate (AA), the amount describes how upstream biosynthetic pathways effect the formation of lipid mediators of irritation, displaying the metabolic interrelationship among all AA-derived mediators.

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Arachidonate Remodeling and Inflammation (Progress in Inflammation Research) by Alfred N. Fonteh,Robert L. Wykle

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